Neuropsychiatric manifestation of confusional psychosis due to Cryptococcus neoformans var. grubii in an apparently immunocompetent host: a case report

doi:10.1186/1757-1626-2-9084

Cases Journal

Volume 2

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Case Report

Neuropsychiatric manifestation of confusional psychosis due to Cryptococcus neoformans var. grubii in an apparently immunocompetent host: a case report

Peralam Yegneswaran Prakash and Rao P Sugandhi

Department of Microbiology, 2nd Floor, Centre for Basic Sciences Building, Kasturba Medical College, Manipal University, Madhav Nagar, Manipal, Karnataka, 576104, India

author email corresponding author email

Cases Journal 2009, 2:9084doi:10.1186/1757-1626-2-9084


Published:	25 November 2009

Abstract

Cognitive disorders like dementia, delirium, depression, anxiety, psychosis and mania are the commonest neuropsychiatric manifestations. We discuss here a case of an adult women presenting with neuropsychiatric manifestations of confusional psychosis owing to Cryptococcosis. The principal cause was consequently established by culturing Cryptococcus neoformans from the cerebrospinal fluid confirmed as C. neoformans var. grubii (Serotype A) by genotypic methods. Antifungal therapy with IV Amphotericin B lead to sustained improvement and recovery of the patient from behavioural disorders. The case discussed here invokes the need for the vigilance it demands in delineating organic brain syndromes for a favourable treatment outcome.