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A rare case of multicentric synchronous bi-frontal glioma in a young female. Diagnostic and therapeutic problems: a case report

Maria Cristina Turola1*, Roberta Schivalocchi2, Vania Ramponi2, Alessando De Vito3, Maria Giulia Nanni4 and Giovanni Francesco Frivoli4

Author Affiliations

1 Servizio Psichiatrico Diagnosi e Cura AUSL Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy

2 U.O. Neurochirurgia, Azienda Ospedaliero-Universitaria S. Anna, Corso Giovecca 203 44100 Ferrara, Italy

3 Unità Operativa Neurologia, Azienda Ospedaliero-Universitaria Ferrara, Corso Giovecca 203, 4410 Ferrara, Italy

4 Clinica Psichiatrica Università di Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy

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Cases Journal 2009, 2:81  doi:10.1186/1757-1626-2-81

Published: 23 January 2009


Multicentric glioblastoma is a uncommon brain malignant tumour.

We report the case of a 43-years-old woman, born in Ukraine and living in Italy, who manifested an initial isolated epileptic seizure and subsequent atypical psychiatric symptoms. Clinical neurological examination, Brain Computed Tomography and standard EEG examinations were negative at the moment of admission. A month later, she presented apathy, apraxia, psychomotor slowdown and expressive aphasia. A Magnetic Resonance Imaging examination showed a bi-frontal lesion. The patient underwent to two neurosurgical removals of the lesions: histological examination demonstrated the presence of a grade IV glioblastoma.

Clinical onset, diagnostic and therapeutic problems are discussed.

In case of atypical psychiatric presentation, it should be taken into consideration neoplastic, inflammatory or infective causes. Despite the absence of focal neurological signs and basal CT scan and EEG alterations, complementary imaging examinations, such as MRI and contrast enhancement CT, are necessary, especially when the conditions become quickly worse