Case Report

The role of diclofenack on inducing of aplasia cutis congenita: a case report

Laura Pajaziti, Syzana Rexhepi, Ylfete Shatri-Muça and Mybera Ferizi

Department of Dermatology, University Clinical Centre of Kosovo, Prishtina, Republic of Kosovo

Cases Journal 2009, 2:150doi:10.1186/1757-1626-2-150

Published:	12 October 2009

Abstract

Background

Aplasia cutis congenita is a disorder where e newborn child is missing skin from certain areas. It is a rare condition with no particular race or sex more at risk. May occur by itself or be associated with other physical syndromes or disorders. A classification system exists for aplasia cutis congenital consisting of 9 groups, based on the number and location of the skin defects and the presence or absence of other malformations. Causes of aplasia congenital could be heredity, teratogenic substances, placental infarcts, intrauterine infections, ectodermal dysplasias etc. Diagnosis is made based on the clinical findings. Prognosis depends of the other organs malfunction level and lesions size.

Case report

Our case was an 22 months old Albanian girl, who was recommended to dermatology for a consultation by a pediatric surgeon because of the changes she had on her parietal part of the scalp with missing hair areas. The child has stenosis congenita ani and to her was installed stoma. In order to investigate other accompanied anomalies of the disease, there are made specific consults by neurologist, orthopedist, cardiologist, nephrologists and citogenetics.

Conclusion

It was found out a minor visual discoordination, Sy Floppy, Digiti V superductus pedis bill. Laxitas articularum generalisata.

It was a great challenge for us to find out that during the first trimester of the pregnancy (unplanned pregnancy), her mother used Diclofenac.

Since there is limited information regarding to teratogenic effects of diclofenac, we considered it interesting to present this case.