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Open Access Highly Accessed Case Report

Hyaline vascular- type Castleman's disease in the hilum of liver: a case report

Hossein Karami1*, Alireza Alam Sahebpour2, Maryam Ghasemi3, Hasan Karami4, Mojdeh Dabirian5, Kurosh Vahidshahi6, Farzad Masiha6 and Soheila Shahmohammadi7

Author Affiliations

1 Department of Pediatric Oncology & Hematology, Thalassemia Research Center, Mazandaran University of Medical Sciences, Booali Sina Hospital, Pasdaran Boulevard, Sari, Po Box: 48158-38477, Iran

2 Department of Pediatric Surgery, Mazandaran University of Medical Sciences, Booali Sina Hospital, Pasdaran Boulevard, Sari, Po Box: 48158-38477, Iran

3 Department of Pathology, Mazandaran University of Medical Sciences, Booali Sina Hospital, Pasdaran Boulevard, Sari, Po Box: 48158-38477, Iran

4 Department of Pediatric Gastroenterology, Mazandaran University of Medical Sciences, Booali Sina Hospital, Pasdaran Boulevard, Sari, Po Box: 48158-38477, Iran

5 Department of Cardiology, Mazandaran University of Medical Sciences, Faculty of Medicine, Sari, PO Box: 48471-91971, Iran

6 Department of Pediatrics, Mazandaran University of Medical Sciences, Faculty of Medicine, Sari, PO Box: 48471-91971, Iran

7 Clinical Research Development Center, Booali Sina Hospital, Pasdaran Boulevard, Sari, Po Box: 48158-38477, Iran

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Cases Journal 2010, 3:74  doi:10.1186/1757-1626-3-74

Published: 1 March 2010

Abstract

Background

Castleman's disease or angiofollicular lymphoid hyperplasia is a rare benign lymph node hyperplasia usually presenting as an asymptomatic mediastinal mass in children. The disease can present at any extra thoracic site with lymphoid tissue such as retroperitoneal, mesentery, axilla, and pelvis. Hepatic localization castleman disease is very rare in children. Herein, we reported a case of Castleman's disease arising from the lymph node in hilum of liver.

Case presentation

A 5 -year-old girl with chief complaint of abdominal pain for two months which exaggerated in last three days was referred to the hospital. On routine physical examination, only a generalized abdominal pain was noticed. Routine laboratory investigations and Chest X-Ray were normal. Abdominal Sonography revealed a 3.7 × 3.1 cm solid mass in the hilum of the liver. On the MRI images, a lobulated mass in the portal hepatic associated with mass effect on the portal vein was visible. Histological examination revealed expansion of mantle zone in lymphatic nodules accompanied by burnt out germinal centers. This pattern was matched with the diagnosis of the hyaline-vascular type of Castleman disease. The patient underwent a laparotomy. The patient had an uneventful postoperative course.

Conclusion

This pattern was matched with the diagnosis of the hyaline-vascular type of Castleman disease.