Prosthetic rehabilitation of hypophosphatasia: a case report

doi:10.1186/1757-1626-2-7626

Cases Journal

Volume 2

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Research article

Prosthetic rehabilitation of hypophosphatasia: a case report

Bora Bağiş¹ , Esra Baltacioğlu² , Elif Aydoğan³ and Evşen Tamam⁴

¹Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey

²Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey

³Research Assistant, Department of Periodontology, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey

⁴DDS, PhD, Private Practice, Ankara, Turkey

author email corresponding author email

Cases Journal 2009, 2:7626doi:10.1186/1757-1626-2-7626


Published:	12 December 2008

Abstract

Hypophosphatasia is a congenital disease characterized by deficiency of serum and tissue non-specific alkaline phosphatase activity. The disease occurs due to mutations in the liver/bone/kidney alkaline phosphatase gene. Six clinical forms of hypophosphatasia are recognized. Systemic symptoms of the disease are respiratory complications, premature craniosynostosis, widespread demineralization and rachitic changes in the metaphases, stress fractures, chondrocalcinosis and osteoarthropathy. Characteristic dental symptoms are premature deciduous teeth loss, premature exfoliation of fully rooted primary teeth, severe dental caries and alveolar bone loss. This clinical report describes the prosthetic rehabilitation of a twenty two year-old Turkish female patient with hypophosphatasia.