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Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report

Jennifer De la Pena and Irene Wapnir*

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300 Pasteur Dr. H3625 Stanford, CA 94305, USA

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Cases Journal 2008, 1:301  doi:10.1186/1757-1626-1-301

Published: 7 November 2008


A 50 year old woman with a 10-year history of systemic lupus erythematosus (SLE) and intermittent low-dose cyclophosphamide therapy developed a palpable mass at the periphery of her left breast. Ultrasound guided core biopsy revealed a spindle cell neoplasm characterized on final pathology as a low grade leiomyosarcoma.