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Open Access Open Badges Case Report

Ascending sensory motor polyradiculoneuropathy with cranial nerve involvement following administration of intrathecal methotrexate and intravenous cytarabine in a patient with acute myelogenous leukemia: a case report*

Richard A Rison

Author Affiliations

Whittier Presbyterian Intercommunity Hospital Stroke Center, University of Southern California, Keck School of Medicine, Los Angeles County Medical Center, Neurology Consultants Medical Group, Whittier, California, USA

Cases Journal 2008, 1:255  doi:10.1186/1757-1626-1-255

Published: 21 October 2008



Acute inflammatory polyradiculoneuropathy secondary to chemotherapy for leukemia has been described in the pediatric literature. However, the reports are rare and have been mainly from intrathecal methotrexate in pediatric acute lymphoblastic leukemia patients who developed demyelinating polyradiculoneuropathy.

Case presentation

A case report is presented of an unfortunate 53 year old Hispanic woman with acute myelogenous leukemia who developed profound weakness with cranial nerve palsies following both intravenous and intrathecal chemotherapy.


This is an interesting and unusual case of predominantly axonal ascending sensory motor polyradiculoneuropathy with cranial nerve involvement in an adult patient with acute myelogenous leukemia following intravenous Cytosine arabinoside and intrathecal methotrexate.