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Open Access Case Report

Ultrastructural pathology of nephropathies with organized deposits: a case series

Fabio Fabbian1*, Nevio Stabellini1, Adriana Galdi1, Sergio Sartori2, Arrigo Aleotti3 and Luigi Catizone1

Author Affiliations

1 Renal Unit, St. Anna Hospital, Corso Giovecca 203, 44100 Ferrara, Italy

2 Internal Medicine, St. Anna Hospital, Corso Giovecca 203, 44100 Ferrara, Italy

3 Electron Microscopy Service, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy

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Cases Journal 2008, 1:184  doi:10.1186/1757-1626-1-184

Published: 25 September 2008

Abstract

Renal organized or structured deposits are much less frequent than those with usual type immunocomplex deposits and are encountered in a wide variety of primary and systemic disorders. It has been suggested that immunoglobulins (Igs) are responsible for organized deposits. We report 5 cases who have been diagnosed and treated in our hospital. Patients were aged 52 to 72 years, three of them were males and had variable degree of renal function, from normal serum creatinine to uraemia. Proteinuria was detected in all patients while monoclonal component was present only in the serum of one subject. Ultrastructural analysis of renal specimens revealed organized deposits. Diagnoses that were made are the following: membranoproliferative glomerulonephritis with finger print, immunotactoid glomerulopathy, membranoproliferative glomerulonephritis with arched deposits, primary amyloidosis and light chain deposition disease. In systemic disorders ultrastructural pathology could be particularly valuable for correct deposits classification, precise localization and pattern of deposition of Igs.